English+GermanWikipedia - /page/entry.mu

Micron Document

<!DOCTYPE html>

<title>Prostacyclinsynthase</title>

</head>

<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Prostacyclinsynthase</span></h1>

</header>

</div>

<th colspan="3" style="background:#90EE90; color:#202122;">Prostacyclinsynthase

</th></tr>

</td></tr>

<tr>

<td colspan="3" class="hintergrundfarbe1" style="text-align:center; font-size:smaller; font-weight:bold;">Bändermodell mit Häm im Zentrum (Kalotten) nach <a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2IAG">2IAG</a>

</td></tr>

<tr>

<p>Vorhandene Strukturdaten: <a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2iag">2iag</a>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3b6h">3b6h</a></span>

</p>

</td></tr>

<tr>

<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins

</th></tr>

<tr>

<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>

</td>

<td colspan="2" style="text-align:center;">57,1 <a href="Atomare_Masseneinheit" title="Atomare Masseneinheit">Kilodalton</a> / 500 Aminosäuren

</td></tr>

<tr>

<td><a href="Sekund%C3%A4rstruktur" title="Sekundärstruktur">Sekundär-</a> bis <a href="Quart%C3%A4rstruktur" title="Quartärstruktur">Quartärstruktur</a>

</td>

<td colspan="2" style="text-align:center;">single pass Membranprotein

</td></tr>

<tr>

<td><a href="Koenzym" class="mw-redirect" title="Koenzym">Kofaktor</a>

</td>

<td colspan="2" style="text-align:center;">Häm-Thiolat

</td></tr>

<tr>

<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner

</th></tr>

<tr>

<td><a href="Human_Genome_Organisation" title="Human Genome Organisation">Gen-Namen</a>

</td>

<td colspan="2" class="" style="text-align:center;"><i><a rel="nofollow" class="external text" href="https://www.genenames.org/tools/search/#!/all?query=9603">PTGIS</a></i>, CYP8A1

</td></tr>

<tr>

<td>Externe IDs

</td>

<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q16647">Q16647</a></li>

</td></tr>

<tr>

<th colspan="3" style="background:#90EE90; color:#202122;">Enzymklassifikation

</th></tr>

<tr>

<td><a href="EC-Nummer" title="EC-Nummer">EC, Kategorie</a>

</td>

<td colspan="2" class="" style="text-align:center;"><a rel="nofollow" class="external text" href="https://www.brenda-enzymes.org/enzyme.php?ecno=5.3.99.4">5.3.99.4</a>, <a href="Isomerase" class="mw-redirect" title="Isomerase">Isomerase</a>

</td></tr>

<tr>

<td>Reaktionsart

</td>

<td colspan="2" style="text-align:center;">Umlagerung

</td></tr>

<tr>

<td>Substrat

</td>

<td colspan="2" style="text-align:center;">Prostaglandin H2

</td></tr>

<tr>

<td>Produkte

</td>

<td colspan="2" style="text-align:center;">Prostacyclin

</td></tr>

<tr>

<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen

</th></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;">Homologie-Familie

</td>

<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=Q16647">Hovergen</a>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;">Übergeordnetes <a href="Taxon" title="Taxon">Taxon</a>

</td>

<td colspan="2" style="text-align:center;"><a href="Wirbeltiere" title="Wirbeltiere">Wirbeltiere</a>

</td></tr>

<tr>

<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a>

</td></tr>

<tr>

</td>

<td style="background:#C3FDB8; color:#202122; text-align:center;">Mensch

</td>

<td style="background:#C3FDB8; color:#202122; text-align:center;">Hausmaus

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>

</td>

</td>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="Ensembl" title="Ensembl">Ensembl</a>

</td>

</td>

<td><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000017969;db=core">ENSMUSG00000017969</a></small></small></span>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>

</td>

</td>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (mRNA)

</td>

</td>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (Protein)

</td>

</td>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="Genlocus" title="Genlocus">Genlocus</a>

</td>

</td>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche

</td>

</td>

</p>

</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>

</p><p><b>Prostacyclinsynthase</b> (<a href="Gen" title="Gen">Gen</a>: <i>PTGIS</i>) ist das <a href="Enzym" title="Enzym">Enzym</a>, das die <a href="Umlagerung" title="Umlagerung">Umlagerung</a> von <a href="Prostaglandin_H2" title="Prostaglandin H2">Prostaglandin H2</a> nach <a href="Prostacyclin" title="Prostacyclin">Prostacyclin</a> <a href="Katalyse" title="Katalyse">katalysiert</a>. Diese Reaktion ist das Gegengewicht zur Umwandlung nach <a href="Thromboxan_A2" title="Thromboxan A2">Thromboxan A2</a>, und auch die Reaktionsprodukte sind physiologische Gegenspieler. Die Synthase kommt in <a href="Wirbeltiere" title="Wirbeltiere">Wirbeltieren</a> vor. Beim Menschen ist sie als <a href="Membranprotein" title="Membranprotein">Membranprotein</a> in allen Gewebetypen, besonders aber in <a href="Ovarien" class="mw-redirect" title="Ovarien">Ovarien</a>, <a href="Herz" title="Herz">Herz</a>, <a href="Skelettmuskel" title="Skelettmuskel">Skelettmuskeln</a>, <a href="Lunge" title="Lunge">Lunge</a> und <a href="Prostata" title="Prostata">Prostata</a> zu finden.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>

</p><p>Prostacyclinsynthase ist in der Membran des <a href="Endoplasmatisches_Reticulum" class="mw-redirect" title="Endoplasmatisches Reticulum">endoplasmatischen Reticulums</a> auf der Innenseite lokalisiert und ist über ein Fusionsprotein eng assoziiert mit den Enzymen <a href="Cyclooxygenase-1" title="Cyclooxygenase-1">COX-1</a>/<a href="Cyclooxygenase-2" title="Cyclooxygenase-2">COX-2</a>. Als Gegenspieler einer Thromboxan A2-erzeugten <a href="Thrombose" title="Thrombose">Thrombose</a> ist die Prostacyclinsynthase ein <a href="Gentherapie" title="Gentherapie">gentherapeutisches</a> <a href="Target_(Biologie)" title="Target (Biologie)">Target</a> für die Behandlung der <a href="Pulmonale_Hypertonie" title="Pulmonale Hypertonie">pulmonalen Hypertonie</a>.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Katalysierte_Reaktion">Katalysierte Reaktion</h2></div>

</p><p>Prostaglandin H2 wird zu Prostaglandin I2 (Prostacyclin) umgelagert.

</p>

<div class="mw-heading mw-heading2"><h2 id="Weitere_Funktionen">Weitere Funktionen</h2></div>

<p>Bestimmte Varianten der Prostacyclinsynthase waren assoziiert mit schwerem Verlauf einer <a href="Respiratory-Syncytial-Virus" class="mw-redirect" title="Respiratory-Syncytial-Virus">Respiratory-Syncytial-Virus</a>-Infektion japanischer Kinder.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Regulation">Regulation</h2></div>

<p>Signaltransduktion von <a href="Tretinoin" title="Tretinoin">Tretinoin</a> über den Retinsäure-Rezeptor erhöht die Expression von Prostacyclinsynthase. Enzymaktivität wird gehemmt durch Peroxynitrit, was durch <a href="Glutathion" title="Glutathion">Glutathion</a> oder <a href="Vitamin_C" class="mw-redirect" title="Vitamin C">Vitamin C</a> verhindert wird.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Weblinks">Weblinks</h2></div>

<div class="sisterproject" style="margin:0.1em 0 0 0;"><div class="noviewer" style="display:inline-block; line-height:10px; min-width:1.6em; text-align:center;" aria-hidden="true" role="presentation"><span class="mw-default-size" typeof="mw:File"><span title="Wikibooks"></span></span></div><b><a href="https://de.wikibooks.org/wiki/Biochemie_und_Pathobiochemie:_Arachidons%C3%A4ure-Stoffwechsel" class="extiw external" title="b:Biochemie und Pathobiochemie: Arachidonsäure-Stoffwechsel">Wikibooks: Biochemie und Pathobiochemie: Arachidonsäure-Stoffwechsel</a></b> – Lern- und Lehrmaterialien</div>

<ul><li>Jassal/D’Eustachio/reactome.org: <a rel="nofollow" class="external text" href="https://reactome.org/content/detail/R-HSA-76496"><i>Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2</i></a></li></ul>

<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>

<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q16647">Q16647</a></span>

</li>

<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text">Wu KK, Liou JY: <cite style="font-style:italic">Cellular and molecular biology of prostacyclin synthase</cite>. In: <cite style="font-style:italic"><a href="Biochem._Biophys._Res._Commun." class="mw-redirect" title="Biochem. Biophys. Res. Commun.">Biochem. Biophys. Res. Commun.</a></cite> 338. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, Dezember 2005, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>45–52</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.bbrc.2005.08.021">10.1016/j.bbrc.2005.08.021</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/16115610?dopt=Abstract">PMID 16115610</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Prostacyclinsynthase&rft.atitle=Cellular+and+molecular+biology+of+prostacyclin+synthase&rft.au=Wu+KK%2C+Liou+JY&rft.date=2005-12&rft.doi=10.1016%2Fj.bbrc.2005.08.021&rft.genre=journal&rft.issue=1&rft.jtitle=Biochem.+Biophys.+Res.+Commun.&rft.pages=45-52&rft.pmid=16115610&rft.volume=338.+Jahrgang" style="display:none"> </span></span>

</li>

<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text">Ruan KH, Deng H, So SP: <cite style="font-style:italic">Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin</cite>. In: <cite style="font-style:italic"><a href="Biochemistry" title="Biochemistry">Biochemistry</a></cite>. 45. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>47</span>, November 2006, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>14003–11</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1021/bi0614277">10.1021/bi0614277</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17115695?dopt=Abstract">PMID 17115695</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Prostacyclinsynthase&rft.atitle=Engineering+of+a+protein+with+cyclooxygenase+and+prostacyclin+synthase+activities+that+converts+arachidonic+acid+to+prostacyclin&rft.au=Ruan+KH%2C+Deng+H%2C+So+SP&rft.date=2006-11&rft.doi=10.1021%2Fbi0614277&rft.genre=journal&rft.issue=47&rft.jtitle=Biochemistry&rft.pages=14003-11&rft.pmid=17115695&rft.volume=45.+Jahrgang" style="display:none"> </span></span>

</li>

<li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text">Ito T, Okada T, Mimuro J, <i>et al</i>: <cite style="font-style:italic">Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats</cite>. In: <cite style="font-style:italic">Hypertension</cite>. 50. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>3</span>, September 2007, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>531–6</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1161/HYPERTENSIONAHA.107.091348">10.1161/HYPERTENSIONAHA.107.091348</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17635855?dopt=Abstract">PMID 17635855</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Prostacyclinsynthase&rft.atitle=Adenoassociated+virus-mediated+prostacyclin+synthase+expression+prevents+pulmonary+arterial+hypertension+in+rats&rft.au=Ito+T%2C+Okada+T%2C+Mimuro+J%2C+...&rft.date=2007-09&rft.doi=10.1161%2FHYPERTENSIONAHA.107.091348&rft.genre=journal&rft.issue=3&rft.jtitle=Hypertension&rft.pages=531-6&rft.pmid=17635855&rft.volume=50.+Jahrgang" style="display:none"> </span></span>

</li>

<li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text">Hashimoto K, Ishibashi K, Gebretsadik T, <i>et al</i>: <cite style="font-style:italic">Functional polymorphism of the promoter region of the prostacyclin synthase gene and severity of RSV infection in hospitalized children</cite>. In: <cite style="font-style:italic">J. Med. Virol.</cite> 80. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>11</span>, November 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>2015–22</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1002/jmv.21318">10.1002/jmv.21318</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18814254?dopt=Abstract">PMID 18814254</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Prostacyclinsynthase&rft.atitle=Functional+polymorphism+of+the+promoter+region+of+the+prostacyclin+synthase+gene+and+severity+of+RSV+infection+in+hospitalized+children&rft.au=Hashimoto+K%2C+Ishibashi+K%2C+Gebretsadik+T%2C+...&rft.date=2008-11&rft.doi=10.1002%2Fjmv.21318&rft.genre=journal&rft.issue=11&rft.jtitle=J.+Med.+Virol.&rft.pages=2015-22&rft.pmid=18814254&rft.volume=80.+Jahrgang" style="display:none"> </span></span>

</li>

<li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text">Camacho M, Rodríguez C, Salazar J, <i>et al</i>: <cite style="font-style:italic">Retinoic acid induces PGI synthase expression in human endothelial cells</cite>. In: <cite style="font-style:italic">J. Lipid Res.</cite> 49. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>8</span>, August 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>1707–14</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1194/jlr.M700559-JLR200">10.1194/jlr.M700559-JLR200</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18458045?dopt=Abstract">PMID 18458045</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Prostacyclinsynthase&rft.atitle=Retinoic+acid+induces+PGI+synthase+expression+in+human+endothelial+cells&rft.au=Camacho+M%2C+Rodr%C3%ADguez+C%2C+Salazar+J%2C+...&rft.date=2008-08&rft.doi=10.1194%2Fjlr.M700559-JLR200&rft.genre=journal&rft.issue=8&rft.jtitle=J.+Lipid+Res.&rft.pages=1707-14&rft.pmid=18458045&rft.volume=49.+Jahrgang" style="display:none"> </span></span>

</li>

<li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text">Zou MH: <cite style="font-style:italic">Peroxynitrite and protein tyrosine nitration of prostacyclin synthase</cite>. In: <cite style="font-style:italic">Prostaglandins Other Lipid Mediat.</cite> 82. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1–4</span>, Januar 2007, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>119–27</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.prostaglandins.2006.05.005">10.1016/j.prostaglandins.2006.05.005</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17164139?dopt=Abstract">PMID 17164139</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Prostacyclinsynthase&rft.atitle=Peroxynitrite+and+protein+tyrosine+nitration+of+prostacyclin+synthase&rft.au=Zou+MH&rft.date=2007-01&rft.doi=10.1016%2Fj.prostaglandins.2006.05.005&rft.genre=journal&rft.issue=1-4&rft.jtitle=Prostaglandins+Other+Lipid+Mediat.&rft.pages=119-27&rft.pmid=17164139&rft.volume=82.+Jahrgang" style="display:none"> </span></span>

</li>

</ol></div><div><div class="zim-footer">

Dieser Artikel wurde von <a class="external text" title="Zuletzt bearbeitet am 2025-02-16" href="https://de.wikipedia.org/wiki/?title=Prostacyclinsynthase&oldid=253392404">Wikipedia</a> herausgegeben. Der Text ist unter <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.de">Creative Commons Attribution-Share Alike 4.0</a> verfügbar, sofern nicht anders angegeben. Für die Mediendateien können zusätzliche Bedingungen gelten.

</div>

</div></div>

</div>

</main>

</div>

</body></html>